5-HIAA urine test
HIAA; 5-hydroxyindole acetic acid; Serotonin metabolite5-HIAA is a urine test that measures the amount of 5-hydroxyindoleacetic acid (5-HIAA). 5-HIAA is a breakdown product of a hormone called serotonin.
This test tells how much 5-HIAA the body is producing, which reflects how much serotonin is in the body.
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How the Test is Performed
A 24-hour urine sample is needed. You'll need to collect your urine over 24 hours in a container provided by the lab. Your health care provider will tell you how to do this. Follow instructions exactly.
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How to Prepare for the Test
Your provider will instruct you, if necessary, to stop taking medicines that may interfere with the test.
Medicines that can increase 5-HIAA measurements include acetaminophen (Tylenol), acetanilide, phenacetin, glyceryl guaiacolate (found in many cough syrups), methocarbamol, and reserpine.
Medicines that can decrease 5-HIAA measurements include heparin, isoniazid, levodopa, monoamine oxidase inhibitors, methenamine, methyldopa, phenothiazines, and tricyclic antidepressants.
You will be told not to eat certain foods for 3 days before the test. Foods that can interfere with 5-HIAA measurements include plums, pineapples, bananas, eggplant, tomatoes, avocados, and walnuts.
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How the Test will Feel
The test involves only normal urination, and there is no discomfort.
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Why the Test is Performed
This test measures the level of 5-HIAA in the urine. It is often done to detect certain tumors in the digestive tract (carcinoid tumors) and to track the progress of a person with a carcinoid tumor.
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Normal Results
The normal range is 2 to 9 mg/24h (10.4 to 46.8 µmol/24h).
Normal value ranges may vary slightly among different lab. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test results.
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What Abnormal Results Mean
Abnormal results may be due to:
- Tumors of the endocrine system or carcinoid tumors
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Risks
There are no risks with this test.
References
Riley RS, McPherson RA. Basic examination of urine. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 29.
Wolin EM, Jensen RT. Neuroendocrine neoplasms. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 213.